Pemetaan Bioaktivitas Senyawa pada Kantung Tinta Cumi-cumi (Loligo vulgaris) Secara In Silico
Abstract
Fish resources according to the Fisheries Law are the potential of all types of fish, including molluscs (squid, and others). Squid (Loligo vulgaris) is a class of Cephalopoda, which is a nutritious food ingredient and has high economic value, but there is still lack of information about its health benefits. Loligo vulgaris has a special characteristic of ink bags that are used as a form of defense against enemies. In its application in life the ink bag always forms a waste material. Utilization of squid ink waste is still limited. The purpose of this study was to analyze and perform a virtual mapping related to the bioactivity of secondary metabolites of Loligo vulgaris. This study used an in silico approach, information on the content of compounds in squid 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (CID: 119405), 5,6-dihydroxyindole (DHI) (CID: 114683) and 2-carboxyl indole (CID: 72899 ), melanin (CID: 6325610), cinnamic acid (CID:), betaine (CID: 247), and choline (CID: 305) were obtained from the NCBI PubChem database. PASS two way drug program and analyzed with Origin Pro 2021 for mapping or heatmap display. The results showed that Squid Ink (Loligo vulgaris) contains melanin, 5,6-dihydroxyindole-2-carboxylic acid (DHICA), 5,6-dihydroxyindole (DHI) and 2-carboxyl indole, cinnamic acid, betaine, and choline. has pharmacological properties as the main ingredient in therapy as anti-inflammatory (eighteen anti-inflammatory parameters), antioxidant (sixteen antioxidant parameters) and as antibacterial (eight antibacterial parameters). The conclusion that squid ink can be used as anti-inflammatory, antioxidant and antibacterial therapy.
References
Ariani, D. NM, Jelantik Swasta IB., Budi Adnyana P. (2019). Studi tentang Keanekaragaman dan Kemelimpahan Mollusca Bentik serta Faktor-Faktor Ekologis yang Mempengaruhinya di Pantai Mengening, Kabupaten Badung, Bali. Jurnal Pendidikan Biologi Undiksha. https://ejournal.undiksha.ac.id/index.php/JJPB/index
Bare, Y., & Sari, D. R. T. (2021). Pengembangan Lembar Kerja Mahasiswa (LKM) Berbasis Inkuiri Pada Materi Interaksi Molekuler. BioEdUIN, 11(1), 8. https://doi.org/10.15575/bioeduin.v11i1.12077
Bare, Y., Sari, D. R. T., Rachmad, Y. T., Krisnamurti, G. C., & Elizabeth, A. (2019). In Silico Insight the Prediction of Chlorogenic Acid in Coffee through Cyclooxygenase-2 (COX2) Interaction. Biogenesis: Jurnal Ilmiah Biologi, 7(2), 100–105. https://doi.org/10.24252/bio.v7i2.9847
Bare, Yohanes, Maria Helvina, Gabriella Chandrakirana Krisnamurti, and Mansur S. 2020. “The Potential Role of 6-Gingerol and 6-Shogaol as ACE Inhibitors in Silico Study.” Biogenesis: Jurnal Ilmiah Biologi 8(2):210. doi: 10.24252/bio.v8i2.15704.
Bharat Technology, Banitabla, Uluberia, Howrah, West Bengal, Halder, D., Pahari, S. K., & Bharat Technology, Banitabla, Uluberia, Howrah, West Bengal. (2020). An Overviw of Sea Cucumber: Chemistry and Pharmacology of Its Metabolites. Indian Research Journal Of Pharmacy And Science, 7(2), 2277–2298. https://doi.org/10.21276/irjps.2020.7.2.19
Chandrasekara, A., & Shahidi, F. (2010). Content of Insoluble Bound Phenolics in Millets and Their Contribution to Antioxidant Capacity. Journal of Agricultural and Food Chemistry, 58(11), 6706–6714. https://doi.org/10.1021/jf100868b
Cikesh, P. C., Karthikeyan, P., Bindiya, E. S., Subin, S. R., Tina, K. J., Chandrasekaran, M., & Bhat, S. G. (2014). Characterization of a Bioactive Protein with Antimicrobial Property from Loligo sp. 6.
Elfi, T. N., Bunga, Y. N., & Bare, Y. (2021). Studi Aktivitas Biologi Secara In Silico Senyawa Nonivamide Dan Nordihydrocapsaicin Sebagai Anti Inflamasi. Florea : Jurnal Biologi dan Pembelajarannya, 8(2), 82. https://doi.org/10.25273/florea.v8i2.9983
Fitrial, Y., & Khotimah, I. K. (2017). Antibacterial Activity of Melanin from Cuttlefish and Squid Ink. Jurnal Pengolahan Hasil Perikanan Indonesia, 20(2), 266. https://doi.org/10.17844/jphpi.v20i2.17907
Hassaan, M. S., Mohammady, E. Y., Soaudy, M. R., El-Garhy, H. A. S., Moustafa, M. M. A., Mohamed, S. A., & El-Haroun, E. R. (2019). Effect of Silybum marianum seeds as a feed additive on growth performance, serum biochemical indices, antioxidant status, and gene expression of Nile tilapia, Oreochromis niloticus (L.) fingerlings. Aquaculture, 509, 178–187. https://doi.org/10.1016/j.aquaculture.2019.05.006
Idris Affandi, R., Fadjar, M., & Wilujeng Ekawati, A. (2019). Active Compounds on Squid (Loligo sp.) Ink Extract Powder as Immunostimulant Candidate to Against Shrimp Disease. Research Journal of Life Science, 6 (3), 150–161. https://doi.org/10.21776/ub.rjls.2019.006.03.1
Jensen, F. (2007). Introduction to Computional Chemistry, 2nd Ed. Odense.
Kolsi, R. B. A., Gargouri, B., Sassi, S., Frikha, D., Lassoued, S., & Belghith, K. (2017). In vitro biological properties and health benefits of a novel sulfated polysaccharide isolated from Cymodocea nodosa. Lipids in Health and Disease, 16(1), 252. https://doi.org/10.1186/s12944-017-0643-y
Krisnamurti, G. C., Sari, D. R. T., & Bare, Y. (2021). Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study. Makara Journal Of Science, 25(4), 9. https://doi.org/10.7454/mss.v25i4.1248
Li, B., Liu, S., Xing, R., Li, K., Li, R., Qin, Y., Wang, X., Wei, Z., & Li, P. (2013). Degradation of sulfated polysaccharides from Enteromorpha prolifera and their antioxidant activities. Carbohydrate Polymers, 92(2), 1991–1996. https://doi.org/10.1016/j.carbpol.2012.11.088
Mahibalan, S., Stephen, M., Nethran, R. T., Khan, R., & Begum, S. (2016). Dermal wound healing potency of single alkaloid (betaine) versus standardized crude alkaloid enriched-ointment of Evolvulus alsinoides. Pharmaceutical Biology, 54(12), 2851–2856. https://doi.org/10.1080/13880209.2016.1185636
Mangindaan, R. J., Mintjelungan, C. N., & Pangemanan, D. H. C. (2019). Uji Daya Hambat Ekstrak Tinta Cumi-cumi (Loligo sp) terhadap Pertumbuhan Bakteri Streptococcus mutans. Jurnal e-Biomedik, 7(2). https://doi.org/10.35790/ebm.7.2.2019.23877
Mayorca-Guiliani, A., & Erler, J. T. (2013). The potential for targeting extracellular LOX proteins in human malignancy. OncoTargets and Therapy, 6, 1729–1735. https://doi.org/10.2147/OTT.S38110
Nadarajah, S., Vijayaraj, R., & Mani, J. (2017). Therapeutic significance of Loligo vulgaris (Lamarck, 1798) ink extract: A biomedical approach. Pharmacognosy Research, 9(5), 105. https://doi.org/10.4103/pr.pr_81_17
Nasution, F. M., Mardia, R. S., Azri, A., Hutabarat, R. R., Izza, F. Al., & Asfur, R. (2017). Pengaruh pemberian ekstrak tinta cumi (squid ink) terhadap aterosklerosis. Jurnal e-Biomedik, 5(2). https://doi.org/10.35790/ebm.5.2.2017.16612
Nontji, Anugerah. 1993. Laut Nusantara. Jakarta: Penerbit Djambatan.
Rophi, Apriani Herni, Yohanes Bare, and Dewi Ratih Tirto Sari. 2021. “The Potential of Acetylfuran and Furfural from Tamarindus Indica as Lipoxygenase Inhibitor: In Silico Study.” JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 8(2):139. doi: 10.20473/jfiki.v8i22021.139-142.
Rosalina, D., & Utami, E. (2017). Pemanfaatan Rumpon Cumi Bagi Nelayan di Tanjung Pengael dan Tuing Jaya Kabupaten Bangka. Urnal Abdi Insani Universitas Mataram, 4(1). http://abdiinsani.unram.ac.id/index.php/jurnal/article/view/91
Sari, D. R. T., Krisnamurti, G. C., & Bare, Y. (2022). Pemetaan Bioaktivitas Senyawa Metabolit Sekunder Pada Kayu Secang (Caesalpinia sappan) Secara In Silico. Journal Pharmasci (Journal of Pharmacy and Science), 7(1), 8.
Vincentius, A. (2020). Sumber Daya Ikan Ekonomis Penting Dalam Habitat Mangrove. Yogyakarta: Penerbit Deepublish. https://scholar.google.com/scholar?oi=bibs&cluster=4748688795234905831&btnI=1&hl=en
