Uji Aktivitas Kombinasi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Dan Kulit Jeruk Nipis (Citrus aurantifolia) Terhadap Penyembuhan Luka Sayat

  • Naila Saputri Universitas Malahayati Bandar Lampung
  • Nofita Nofita Universitas Malahayati Bandar Lampung
  • Ade Maria Ulfa Universitas Malahayati Bandar Lampung
Keywords: binahong leaves, (Anredera cordifolia (Ten.) Steenis), lime peel (Citrus aurantifolia), wound healing, ointment.

Abstract

Plants that are efficacious as wound healers from natural ingredients, namely binahong leaves and lime peel. This study aims to determine the effectiveness of the combination of binahong leaf extract (Anredera cordifolia (Ten.) Steenis) and lime peel (Citrus aurantifolia) on the healing of cuts in male rats (Rattus noervegicus). In the test animal, an incision was made on the back with a length of 2 cm and a wound depth of 0.2 cm using a scalpel (bisturi). The test animals were divided into six treatment groups: normal control without ointment, negative control given ointment base, positive control given povidone iodine ointment, formulation 1 given extract combination ointment (1:3), formulation 2 given extract combination ointment (1:1). , and formulation 3 was given an extract combination ointment (3:1). Ointment is given twice daily for 14 days. Observation of wound healing was carried out by measuring the decrease in the length of the incision in the test animals. The results showed that the combination ointment of binahong leaf extract and lime peel formulation 1 with concentration (1:3) and formulation 2 with concentration (1:1) experienced healing on the 8th day, formulation 3 with concentration (3:1) experienced recovery on day 9. Statistical results using the Mann Whitney HocPost for the F1, F2, and F3 treatment groups compared to the positive control did not have a significant difference because the value obtained was p> 0.05. It was concluded that the combination ointment of binahong leaf extract and lime peel has healing activity for cuts and can be used as a healer for cuts.

References

Anief M., 2007. Ilmu Meracik Obat, Gadjah Mada University Press, Yogyakarta.

BPOM (Badan Pengawas Obat dan Makanan), 2008. Informatorium Obat Nasional Indonesia, Badan Pengawas Obat dan Makanan Republik Indonesia, Jakarta

Departemen Kesehatan RI, 1986. Sediaan Galenik. Jakarta: Departemen Kesehatan Republik Indonesia.

Departemen Kesehatan RI.1995. Farmakope Indonesia IV. Jakarta: Departemen Kesehatan Republik Indonesia.

Departemen Kesehatan RI.2000. Parameter Standar Umum Ekstrak Tumbuhan Obat.Jakarta.: Direktorat Pengawasan Obat Tradisional.

Eriadi, A, Arifin, H., Rizal, Z., dan Barmitoni. 2015. Pengaruh Ekstrak Etanol Daun Binahong (Anredera cordifolia, (Ten) Steen) Terhadap Penembuhan Luka Sayat Pada Tikus Putih Jantan. Jurnal Farmasi. 7 (2): 162-172.

Gerg, A., Aggarwal, D., Garg, S., & Singla, A.K. 2002. Spreading of Semisolid

Kartika W.R, 2015. Perawatan Luka Kronis dengan Modern Dressing. CDK – 230/Vol. 42.

Kemenkes RI. 2013. Riset Kesehatan Dasar, RISKESDAS. Jakarta: Balitbang Kemenkes RI.

Liana, E. 2017. Pengaruh Konsentrasi Ekstrak Daun Jeruk Nipis (Citrus aurantifolia) Terhadap Mortalitas Larva Nyamuk Aedes Aegypti. Skripsi. Mataram: Fakultas Ilmu Tarbiyah Dan Keguruan (FITK) Institut Agama Islam Negeri (IAIN) Mataram.

Pebriani N. 2017. Pengaruh Pemberian Ekstrak Daun Ketul (Bidens pilosa L.) Terhadap Penyembuhan Luka Sayat Pada Punggung Tikus Putih (Rattus norvegicus). University of Muhammadiyah Malang.

Pratiwi, D., Suswati, I., & Abdullah, M. (2013). Efek Anti Bakteri Ekstrak Kulit Jeruk Nipis (Citrus aurantifolia) Terhadap Salmonella Typhi Secara In Vitro. Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga, 9 (2), 110-115.

Primadiamanti, A., Winahyu, D. A., & Jaulin, A. (2018). Uji Efektivitas Sediaan Salep Batang Pepaya (Carica Papaya L.) Sebagai Penyembuh Luka. Jurnal Farmasi Malahayati, 1(2).

Program K, Pada K, Balai P. 2015. Universitas Islam Negeri Alauddin Makassar Tahun 2015.

Samirana, P. O., D. A. Swastini, I. D. G. P. Y. Subartha, dan Ariadi, K. A. 2017. Uji Aktivitas Penyembuhan Luka Ekstrak Etanol Daun Binahong (Anredera scadens (L.) Moq.) pada Tikus Jantan Galur Wistar. Jurnal Farmasi Udayana. 5(2): 19-23.

Semer, N.B. 2013. Dasar-dasar Perawatan Luka. Jakarta: Global-HELP Organization.

Susetya, D. 2012. Khasiat dan manfaat daun ajaib binahong Yogyakarta: pustaka baru press

Syamsuni, H.A., 2007. Ilmu Resep. EGC. Jakarta.

Ulfa, A. M., Primadiamanti, A., & Alim, F. N. (2021). Uji Efektivitas formulasi salep ekstrak kulit jeruk nipis (citrus aurantifolia) sebagai penyembuhan luka diabetes tipe I pada tikus jantan, Jurnal Farmasi Malahayati.

Yanhendri SWY. 2012. Berbagai bentuk sediaan topikal dalam dermatologi. Cermin Dunia.

Published
2024-05-12
How to Cite
Saputri, N., Nofita, N., & Ulfa, A. (2024). Uji Aktivitas Kombinasi Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis) Dan Kulit Jeruk Nipis (Citrus aurantifolia) Terhadap Penyembuhan Luka Sayat. Jurnal Ilmiah Wahana Pendidikan, 10(9), 488-498. https://doi.org/10.5281/zenodo.11180260

Most read articles by the same author(s)