Serum Ampuh Penghilang Jerawat dan Memperbaiki Kulit yang Rusak Akibat Sinar Matahari dengan Menggunakan Bahan Alami Centella Asiatica
Abstract
Currently, there are many topical anti-acne drugs circulating in the form of gels and creams, but there are still few topical anti-acne that contain herbs, as active ingredients or agents that have the potential to prevent and treat acne such as gotu kola (Centella asiatica (L.) Urb) with its anti-bacterial properties. Objective: To develop a stable gotu kola gel formulation. Method: Testing gotu kola formulation according to the evaluation requirements with a gel base concentration of 7%, 8%, 9%, then the evaluation includes testing of organoleptic, pH, and viscosity. The formula was added with gotu kola herb extract at a concentration of 2.5% and 5%. The formula evaluation tests carried out included observations of homogeneity, tests of acidity, viscosity and spreadability of the preparation. Results: The average pH of the preparation was 6.66. Formula 1 and Formula 2 there is a slight difference in viscosity. Formula 1 and Formula 2 show homogeneity and dispersion that have met the requirements. Conclusion: For 14 days, testing Formula 2 with an extract concentration of 5% was more stable than Formula 1 with an extract concentration of 2.5%.
References
Adria, G. (2009). Uji Aktivitas Krim Ekstrak Etanol Pegagan (Centella asiatica (L) Urb) terhadap Bakteri Penyebab Jerawat. Skripsi; Fakultas Farmasi Universitas Andalas, Padang.
Dewi, R. K. (2010). Optimasi Formulasi Mikroemulsi Sediaan Hormon Testosteron Undekanoat. Skripsi; Fakultas Kedokteran dan Ilmu Kesehatan Universitas Islam Negeri Syarif Hidayatullah, Jakarta.
Ditjen POM. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: DepKes RI.
Djajadisastra, J., Mun’im, A. & Dessy, N. P. (2009). Formulasi Gel Topikal dari Ekstrak Nerii Folium dalam Sediaam Anti Jerawat. Jurnal Farmasi Indonesia; 4; 210-216.
Fauzy, A. (2012). Pengaruh Konsentrasi Minyak Ikan terhadap Penetrasi Kurkumin dalam Sediaan Mikroemulsi Gel.Skripsi; Fakultas Matematika dan Ilmu pengetahuan Alam Universitas Indonesia.
Garg, A. D., Aggarwal, S. G. & Sigla, A. K. (2002). Spreading of Semisolid Formulation. USA: Pharmaceutical Technology.
Kementrian Kesehatan Republik Indonesia, (2014), Farmakope Indonesia (edisi V). Jakarta: Kementrian Kesehatan RI.
Nurahmanto D., Mahrifah I. R. N. & Rosyidi V. A. (2017). Formulasi Sediaan Gel Dispersi Padat Ibuprofen: Studi Geling Angent dan Senyawa Peningka. Ilmiah Manuntung; 3; 96-105.
Nurdianti, L., Azzahra, S. F. & Aji, N. (2017). Pengembangan Formulasi Sediaan Gel Rambut Antiketombe Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) dengan Menggunakan Viscolam sebagai Gelling Agent dan Uji Aktivitasnya terhadap Jamur Pityrosporum ovale. Jurnal Kesehatan Bakti Tunas Husada; 17; 456-467.
Primastuti, R. F. (2013). Antioxidant and Cytotoxic Activities of Centella asiatica L. Leaves and Extract of Green Coffee Beans in a Cream Preparation for Grade 1-3 Cellulite and Slimming. Makara Journal Sains; 17; 1-5.
Sasanti, T. J. Wibowo, M. S., Fidrianny, I. & Caroline, S. (2012). Formulasi Gel Ekstrak Air Teh Hijau dan Penentuan Aktivitas Antibakterinya terhadap Propionibacterium acne. Skripsi: School of Pharmacy ITB.
Sikareepaisan, P., Suksamrarn, A. & Supaphol, P. (2008). Electrospun Gelatin Fiber Mats Containing A Herbal Centella asiatica Extract and Release Characteristic of Asiaticoside. Nanotechnology; 19; 1-10.
Voight, R. (1994). Buku Pelajaran Teknologi Farmasi (Edisi V). Yogyakarta: Gadjah Mada University Press.
Wasitaatmadja, S. (1997). Penuntun Ilmu Kosmetik. Jakarta: Universitas Indonesia Press.


