Kajian Mekanisme Molekuler Golongan Obat Antihipertensi Dalam Menghambat Angiotensin-Converting Enzyme (ACE)
Abstract
Hypertension or increased blood pressure is a chronic disease that requires long treatment, even for life. Patients with hypertension must control their blood pressure to avoid complications. In the body, there are components of the renin-angiotensin system, namely the angiotensin-converting enzyme (ACE) which can indirectly increase blood pressure, so the treatment is to inhibit ACE. In this article, the method used is by literature study of several accredited journals that has published from 2012 to 2022. ACE inhibitor class drugs are often used for the treatment of hypertension because they have a mechanism of inhibiting the conversion enzyme peptidyl dipeptidase, so that angiotensin I is not hydrolyzed to angiotensin II and can be contributed for dilating blood vessels as well so that it effectively lowers blood.
References
Afifah, N. N., Mulyani, Y., & Yuniarto, A. (2021). Review: Pengaruh tanaman obat yang beraktivitas hipertensi terhadap ekspresi gen reseptor ACE-1 dan ACE 2. Jurnal Mandala Pharmacon Indonesia, 7(1), 9–31. https://doi.org/10.35311/jmpi.v7i1.64.
Aulena, D., Tambunan, R., & Desya, P. (2020). Aktivitas antioksidan, penghambatan ACE (angiotensin-converting enzyme), dan toksisitas dari ekstrak etanol 70% daun jamblang (Syzigium cumini L.). Sainstech Farma, 13(2), 99–106.
Borghi, C., Soldati, M., Bragagni, A., & Cicero, A. F. G. (2020). Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients. Expert Opinion on Drug Safety, 19(12), 1577–1583. https://doi.org/10.1080/14740338.2020.1836151.
Dewi, N. P. U. S., Amandari, , I. G. A. A. E., Krisnayanti, M. W., & Sarasmita, M. (2018). Aliskiren: Direct renin inhibitor baru pada terapi hipertensi. Hang Tuah Medical Journal, 16(1), 18. https://doi.org/10.30649/htmj.v16i1.76.
Fakih, T. M., & Dewi, M. L. (2020). Identifikasi Mekanisme Fungsional Senyawa Bioaktif Peptida dari Organisme Laut sebagai Inhibitor Alami Angiotensin-I Converting Enzyme (ACE) secara In Silico. Majalah Farmasi Dan Farmakologi, 24(1), 17–21. https://doi.org/10.20956/mff.v24i1.9647.
Fransiska, A. N., Pratama, A. A., Nurayuni, T., Wulanbirru, P., Cordova, D. M., Advaita, C. V., … Mulki, M. A, Malau J. (2022). Review : Target Aksi Obat Terhadap Reseptor Dopamin. Jurnal Pendidikan dan Konseling. 4, 8706–8716.
Jiofansyah, M. (2020). Angiotensin converting enzyme inhibitor sebagai terapi pasien hipertensi primer dengan obesitas. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 7(2), 147–151. https://doi.org/10.53366/jimki.v7i2.55
Linelejan, B., Umboh, O., & Wantania, F. E. N. (2021). Pengaruh penggunaan angiotensin converting enzyme inhibitor (ACEI) dan angiotensin receptor blocker (ARB) pada pasien coronavirus disease 2019 (covid-19) dengan hipertensi. E-CliniC, 9(1), 104–109. https: //doi.org/10.35790/ecl.v9i1.31963
Majumder, K., & Wu, J. (2014). Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension. International Journal of Molecular Sciences, 16(1), 256–283. https://doi.org/10.3390/ijms16010256
Martín-Peláez, S., Castañer, O., Konstantinidou, V., Subirana, I., Muñoz-Aguayo, D., Blanchart, G., Gaixas, S., de la Torre, R., Farré, M., Sáez, G. T., Nyyssönen, K., Zunft, H. J., Covas, M. I., & Fitó, M. (2015). Effect of olive oil phenolic compounds on the expression of blood pressure-related genes in healthy individuals. European Journal of Nutrition, 56(2), 663–670. https://doi.org/10.1007/s00394-015-1110-z.
Mayasari, S. (2020). Analysis Of The Used Of Captopril Drug With Blood Pressure Of Hypertension Patients. Jurnal Kesehatan Dr. Soebandi, 8(2), 123–127. https://doi.org/10.36858/jkds.v8i2.225
Nuraini, B. (2015). Risk Factors of Hypertension. J Majority, 4(5), 10–19.
Nurul Susanti, Sri Peni Fitrianingsih, & Fetri Lestari. (2022). Studi Literatur Potensi Beberapa Ekstrak Tumbuhan Mengandung Katekin sebagai Antihipertensi. Bandung Conference Series: Pharmacy, 2(2). https: //doi.org/10.29313/bcsp.v2i2.4701
Okamura, M., Ogawa, S., & Ito, S. (2011). Safety and Efficacy of Imidapril in the Treatment of Essential Hypertension. Clinical Medicine Insights: Therapeutics, 3, CMT.S7662. https://doi.org/10.4137/cmt.s7662
Prabasari, N. A. (2021). Self efficacy, self care management, dan kepatuhan pada lansia hipertensi (studi fenomenologi). Jurnal Keperawatan Malang, 6(1), 1–10. https://doi.org/10.36916/jkm.v6i1.115
Praja, R. A., & Pratiwi, D. (2018). Study of molecular placement of sscopoletin compounds from mine (morinda citrifolia l.) in enzim ACE as antihipertension. Farmagazine, 5(1), 31–39.
Purwaningtyas, A. V, & Barliana, M. I. (2021). Review: Efek angiotensin converting enzyme inhibitor (ACEI) dan angiotensin receptor blocker (ARB) sebagai kardioprotektor terhadap cardiovascular events. Farmaka Suplemen, 1, 76–87.
Rahmawati, I. S., Soetjipto, S., Catur Adi, A., Aulanniam, A., & Rizky Maulidiana, A. (2021). Potensi Ekstrak Etanol Ubi Jalar Ungu sebagai Inhibitor Angiotensin Converting Enzyme pada Tikus Hipertensi. Indonesian Journal of Human Nutrition, 8(1), 88–96. https://doi.org/10.21776/ub.ijhn.2021.008.01.9
Rizkaprilisa, W., & Martina Widhi Hapsari. (2022). Potensi ACE (angiotensin-i converting enzyme) inhibitor dari tempe koro – koroan sebagai pangan fungsional antihiperteNSI. Science Technology and Management Journal, 2(1), 20–25. https://doi.org/10.53416/stmj.v2i1.51
Widiasari, S. (2019). Mekanisme Inhibisi Angiotensin Converting Enzym Oleh Flavonoid Pada Hipertensi. Collaborative Medical Journal CMJ, 1(2), 30–44.
Zakiyah, W., Putri, S., Wibowo, S., Elyyana, N., & Nur, S. A. Malau J. (2022). Literature Review : Study of Molecular Mechanism Level of NSAID Class Of Drugs As COX-2 Inhibitors. J Edu healt. 13(02), 572–580.
Xue, L., Feng, X., Wang, C., Zhang, X., Sun, W., & Yu, K. (2017). Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression. BMC Nephrology, 18(1). https://doi.org/10.1186/s12882-017-0724-1
Yenny, K. (2017). Tatalaksana Farmakologi Terapi Hipertensi. Divisi Ginjal Dan Hipertensi RSUP Sanglah Denpasar, 1–12.
