Analisis Karakterisasi Senyawa Obat dan Identifikasi Menggunakan Metode SpektrometriMassa : Tinjauan Literatur

  • Evi Riszka N Universitas Buana Perjuangan Karawang
  • Ermy Abriyani Universitas Buana Perjungan Karawang
  • Fitri Nurfadhilla Universitas Buana Perjungan Karawang
  • Marsella Mideliani J Universitas Buana Perjungan Karawang
  • Wipena Fariza Universitas Buana Perjungan Karawang
Keywords: Spektrometri massa, farmasi, karakterisasi obat, identifikasi obat, obat,senyawa

Abstract

Tinjauan literatur ini membahas penggunaan spektrometri massa untuk menganalisis senyawa karakterisasi obat dan menemukan senyawa aktif dalam industri farmasi. Karena kemampuan spektrometri massa untuk mengidentifikasi senyawa organik dan anorganik dalam sampel obat, spektrometri massa adalah metode analisis yang sangat penting dalam penelitian farmasi. Dalam tinjauan literatur ini, kami akan membahas penggunaan spektrometri massa untuk menentukan kadar obat dalam sediaan farmasi, pengembangan teknik analisis spektrometri massa dalam farmasi, dan penggunaan spektrometri massa dalam penelitian farmasi. Diharapkan tinjauan literatur ini akan membantu peneliti farmasi memahami dan mengembangkan teknik analisis spektrometri massa dalam penelitian farmasi.

References

AGBOKPONTO, J. E., YEMOA, L. A., ASSANHOU, A. G., LIU, R., GANFON, H., & DING, L. (2021). LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY DETERMINATION METHOD OF

BENCYCLOQUIDIUM BROMIDE: APPLICATION TO DRUG INTERACTION STUDY IN HUMAN.

International Journal of Pharmacy and Pharmaceutical Sciences, 43–46. https://doi.org/10.22159/ijpps.2021v13i10.5791

Aji Pamungkas, D., Maria Ulfa, A., & Kurniati, M. (n.d.). PENGARUH JENIS PELARUT PADA METODE MASERASI TERHADAP KARAKTERISTIK EKSTRAK DAUN KAYU PUTIH (Eucalyptus pellita). In

Agustus (Vol. 6).

Al Bara, B., Auladi Rivianto, F., Nurlaela, N., & Sulastri, S. (2021). Isolasi Senyawa Alkaloid Bahan Alam. Jurnal Health Sains, 2(7), 858–870. https://doi.org/10.46799/jhs.v2i7.217

Andika Saputra, S. (n.d.). IDENTIFIKASI BAHAN KIMIA OBAT DALAM JAMU PEGEL LINU SEDUH DAN KEMASAN YANG DIJUAL DI PASAR BANDAR CHEMICAL IDENTIFICATION HERBAL MEDICINE PACKAGING AND SOLD HERBS PEGEL PAINS AT BANDAR MARKET.

Bello, W., Pezzatti, J., Berger-Gryllaki, M., Rudaz, S., & Sadeghipour, F. (2023). Development of a

generic approach for monitoring leachable compounds in hospital pharmacy-prepared prefilled plastic packaging by ultrahigh-performance liquid chromatography coupled to high-resolution mass spectrometry with postcolumn infusion. Journal of Pharmaceutical and Biomedical

Analysis, 236. https://doi.org/10.1016/j.jpba.2023.115640

Cai, R. J., Yin, X. L., Liu, J., Qin, D. X., & Zhao, G. Z. (2017). Characterization and identification of in

vitro metabolites of (-)-epicatechin using ultra-high performance liquid chromatography-mass spectrometry. Tropical Journal of Pharmaceutical Research, 16(12), 2985–2990.

https://doi.org/10.4314/tjpr.v16i12.24

Chiang, C. H., Lee, H. H., Chen, B. H., Lin, Y. C., Chao, Y. Y., & Huang, Y. L. (2019). Using ambient mass spectrometry and LC–MS/MS for the rapid detection and identification of multiple illicit street drugs. Journal of Food and Drug Analysis, 27(2), 439–450.

https://doi.org/10.1016/j.jfda.2018.11.003

Dan, I., Tumbuhan, P., Suku, O., Kabupaten, D. Di, Papua, J., Mabel, Y., Simbala, H., Koneri, R., Biologi, J., A T A K U N C I A B S T R, M. K., Identifikasi, A. K., & Dani, S. (n.d.). JURNAL MIPA UNSRAT ONLINE 5 (2) 103-107.

Decroo, C., Colson, E., Lemaur, V., Caulier, G., De Winter, J., Cabrera-Barjas, G., Cornil, J., Flammang, P., & Gerbaux, P. (2019). Ion mobility mass spectrometry of saponin ions. Rapid

Communications in Mass Spectrometry, 33(S2), 22–33. https://doi.org/10.1002/rcm.8193

Devarajan, S., Moon, I., Ho, M. F., Larson, N. B., Neavin, D. R., Moyer, A. M., Black, J. L., Bielinski, S. J., Scherer, S. E., Wang, L., Weinshilboum, R. M., & Reid, J. M. (2019). Pharmacogenomic next-

generation DNA sequencing: Lessons from the identification and functional characterization of variants of unknown significance in CYP2C9 and CYP2C19. Drug Metabolism and Disposition, 47(4), 425–435. https://doi.org/10.1124/dmd.118.084269

Fiorentino, F., Rotili, D., & Mai, A. (2023). Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation. In Drug Discovery Today (Vol. 28,

Issue 5). Elsevier Ltd. https://doi.org/10.1016/j.drudis.2023.103548

Fleury-Souverain, S., Maurin, J., Guillarme, D., Rudaz, S., & Bonnabry, P. (2022). Development and application of a liquid chromatography coupled to mass spectrometry method for the

simultaneous determination of 23 antineoplastic drugs at trace levels. Journal of

Pharmaceutical and Biomedical Analysis, 221. https://doi.org/10.1016/j.jpba.2022.115034

Fouquet, T., Nakamura, S., & Sato, H. (2016). MALDI SpiralTOF high-resolution mass spectrometry and Kendrick mass defect analysis applied to the characterization of poly(ethylene-co-vinyl acetate) copolymers. Rapid Communications in Mass Spectrometry, 30(7), 973–981. https://doi.org/10.1002/rcm.7525

Gde, D., Yuda Pratama, A., Agung, G., Bawa, G., Wayan, D. I., & Gunawan, G. (n.d.). ISOLASI DAN IDENTIFIKASI SENYAWA MINYAK ATSIRI DARI TUMBUHAN SEMBUKAN (Paederia foetida L.) DENGAN METODE KROMATOGRAFI GAS-SPEKTROSKOPI MASSA (GC-MS).

Hasan, R., Rasyid Kuna, M., & Ismail, S. A. (2023). JAMBURA JOURNAL OF HEALTH SCIENCE AND

RESEARCH ANALISIS BAHAN KIMIA OBAT DALAM JAMU PEGAL LINU MENGGUNAKAN METODE KROMATOGRAFI GAS-SPEKTROMETRI MASSA CHEMICAL DRUG ANALYSIS IN JOINT-PAIN HERBAL MEDICINE USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY METHOD.

https://ejurnal.ung.ac.id/index.php/jjhsr/index

Huang, R. Y. C., Deyanova, E. G., Passmore, D., Rangan, V., Deshpande, S., Tymiak, A. A., & Chen, G. (2015). Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates. Journal of the American Society for Mass Spectrometry, 26(10), 1791–1794. https://doi.org/10.1007/s13361-015-1203-1

Karpushyna, S. A., Baiurka, S. V., & Tomarovska, T. O. (2022). Detection of atomoxetine and its

metabolites in the urine by thin-layer chromatography and mass spectrometry. Current Issues in Pharmacy and Medicine: Science and Practice, 15(1), 25–30. https://doi.org/10.14739/2409- 2932.2022.1.252070

Khadim, Adeeba, Jeelani, Syed Usama Yaseen, Akhtar Naheed,dkk.(2022). Investigation of fragmentation behaviors of steroidal drugs with Li+, Na+, K+ adducts by tandem mass spectrometry aided with computational analysis. Arabian Journal of Chemistry, vol.15. https://doi.org/10.1016/j.arabjc.2022.103939

Kunci, K., Chaira, S., Zaini, E., & Augia, T. (2016). Evaluasi Pengelolaan Obat pada Puskesmas di Kota Pariaman (Drugs Management Evaluation at Community Health Centers in Pariaman City,

Indonesia). Jur Nal Sains Farmasi & Klinis, 3(1), 35–41. http://jsfkonline.org

Lee, C.-W., Su, H., Cai, Y.-D., Wu, M.-T., Wu, D.-C., & Shiea, J. (2017). Rapid Identification of Psychoactive Drugs in Drained Gastric Lavage Fluid and Whole Blood Specimens of Drug

Overdose Patients Using Ambient Mass Spectrometry. Mass Spectrometry, 6(2), S0056–S0056. https://doi.org/10.5702/massspectrometry.s0056

Li, Y., Al-Eryani, R., Yarbrough, M. L., Orth, K., & Ball, H. L. (2011). Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry. Journal of the American Society for Mass Spectrometry, 22(4), 752–761. https://doi.org/10.1007/s13361-011-0084-1

Liu, Y., Zhang, X., Yang, S., Zhou, Z., Tian, L., Li, W., Wei, J., Abliz, Z., & Wang, Z. (2023). Integrated mass spectrometry imaging reveals spatial-metabolic alteration in diabetic cardiomyopathy and the intervention effects of ferulic acid. Journal of Pharmaceutical Analysis.

https://doi.org/10.1016/j.jpha.2023.08.011

Lu, Xiyuan , Hackman, G. Lavender , Saha Achinto,dkk.(2022). Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry. Vol.25. https://doi.org/10.1016/j.isci.2022.104221

Montone ,Carmela Maria, Moneta ,Benedetta Giannelli, Laganà, Aldo Laganà.(2023). Transformation products of antibacterial drugs in environmental water: Identification approaches based on

liquid chromatography-high resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, vol 238. https://doi.org/10.1016/j.jpba.2023.115818

Ross, D. H., Seguin, R. P., & Xu, L. (2019). Characterization of the Impact of Drug Metabolism on the Gas-Phase Structures of Drugs Using Ion Mobility-Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.9b03292

Sajjad Saad Zghair, Sahar Sarhan Thajeel, & Imad Hadi Hameed. (2023). Characterization of

antimicrobial secondary metabolites produced by Klebsiella pneumoniae and screening of its bioactive natural compounds using gas chromatography-mass spectrometry (GC-MS).

International Journal of Life Science Research Archive, 5(1), 076–089. https://doi.org/10.53771/ijlsra.2023.5.1.0071

Suryowati, T., Damanik, R., Bintang, M., & Handharyani, E. (n.d.). IDENTIFIKASI KOMPONEN KIMIA DAN AKTIVITAS ANTIOKSIDAN DALAM TANAMAN TORBANGUN (Coleus amboinicus Lour)

(Identification of chemical compound and antioxidant activity in torbangun [Coleus amboinicus Lour] plant).

Takai, N., Tanaka, Y., & Saji, H. (2014). Quantification of Small Molecule Drugs in Biological Tissue Sections by Imaging Mass Spectrometry Using Surrogate Tissue-Based Calibration Standards. Mass Spectrometry, 3(1), A0025–A0025. https://doi.org/10.5702/massspectrometry.a0025

Thevis, M. M., Thomas, A., Kohler, M., Beuck, S., Möller, I., Schäfer, M., Rodchenkov, G., Yin, S., Loo, J. A., Geyera, H., & Schänzera, W. (2010). Mass spectrometry-based characterization of new drugs and methods of performance manipulation in doping control analysis. European Journal of Mass Spectrometry, 16(3), 301–312. https://doi.org/10.1255/ejms.1047

Tozuka, Z., Aoyama, S., Nozawa, K., Akita, S., Oh-Hara, T., Adachi, Y., & Ninomiya, S. I. (2011). Comprehensive quantitative and qualitative liquid chromatography-radioisotope-mass spectrometry analysis for safety testing of tolbutamide metabolites without standard samples. Journal of Pharmaceutical Sciences, 100(9), 4024–4036. https://doi.org/10.1002/jps.22646

Xu, X., Hu, Q., Liu, D., Qiu, H., Shameem, M., & Li, N. (2021). Characterization of Proteinaceous Particles in Monoclonal Antibody Drug Products Using Mass Spectrometry. Journal of

Pharmaceutical Sciences, 110(10), 3403–3409. https://doi.org/10.1016/j.xphs.2021.06.014

Zhang, F. xiang, Yuan, Y. lin lan, Wang, J. yun, Li, Z. ting, Cui, S. shuang, Zhu, F. cheng, Qiu, D., Wang, Y., & Li, R. man. (2021). Characterization of metabolism feature and potential pharmacological changes of morusin-a promising anti-tumor drug-by ultra-high-performance liquid chromatography coupled time-of-flight mass spectrometry and network pharmacology. Arabian Journal of Chemistry, 14(2). https://doi.org/10.1016/j.arabjc.2020.102964

Published
2024-10-31
How to Cite
N, E., Abriyani, E., Nurfadhilla, F., Mideliani J, M., & Fariza, W. (2024). Analisis Karakterisasi Senyawa Obat dan Identifikasi Menggunakan Metode SpektrometriMassa : Tinjauan Literatur. Jurnal Ilmiah Wahana Pendidikan, 10(20), 270-284. https://doi.org/10.5281/zenodo.14280480